A 75-year-old man presented to the emergency department with diffuse swelling of his tongue that had begun a few hours earlier. He had no known history of allergies. He had been taking antihypertensive twice daily for the past three years . Treatment with which antihypertensive is most likely to cause this appearance?

Beta-blocker
Diuretic
Alpha-blocker
Angiotensin converting-enzyme inhibitor
Calcium-channel blocker











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Correct Answer : Angiotensin converting-enzyme inhibitor

Explanation :


Angioedema of the tongue is most associated with treatment with an angiotensin converting-enzyme inhibitor.


The patient was treated with epinephrine, antihistamines, and corticosteroids; the symptoms resolved over a three-hour period. Laboratory tests subsequently showed that tryptase and complement component levels (C1q, C3, and C4) were normal.



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